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Calcium-dependent electrostatic control of anion access to the pore of the calcium-activated chloride channel TMEM16A
TMEM16A is a ligand-gated anion nacrack.com channel that is activated by intracellular Ca2+.This channel comprises two independent pores and closely apposed Ca2+ binding sites that are contained within each subunit of a homodimeric protein.Previously we characterized the influence of positively charged pore-lining residues on anion conduction (Paul
Testicular and epididymal dysfunctions: searching a new index for the differential diagnosis
Objective: This proof-of-principle aims to develop an index to aid the differential diagnosis of disorders affecting testicular and/or epididymis.A total of 202 subject data were evaluated in two groups: fertile men with children naturally conceived within 1 year of unprotected intercourse (n = 36) and infertile men (n = 166) who had attempted a pr
Variational Learning for the Inverted Beta-Liouville Mixture Model and Its Application to Text Categorization
The finite invert Beta-Liouville mixture model (IBLMM) has recently gained some attention due to its positive data modeling capability.Under the conventional variational inference (VI) framework, the analytically tractable solution to the optimization of the variational posterior distribution cannot be obtained, since cent dyyni the variational obj
Evidence for preferences of Italian patients for physician attire
Giovanni Sotgiu1, Paolo Nieddu2, Laura Mameli2, Enrico Sorrentino2, Pietro Pirina3, Alberto Porcu4, Stefano Madeddu1, Manuela Idini1, Maddalena Di Martino1, Giuseppe Delitala2, Ida Mura1, Maria Pina Dore21Epidemiology and Medical Statistics Unit, Department of Biomedical Sciences, 2Clinica Medica, 3Pneumologia, 4Chirurgia dell’Obesit&